Your CRF design is quite compact and clean. However, there are several points that I would like to suggest. For the year of birth, you should specify the type year such as B.E.(Buddist) or CE(Chrost). The age section can be designed as an open-ended question for more precise information. It would be better if you add more sections on physical examination to provide more detail. The section for lab test reports should also be involved as it is the major finding of this study. You should also remove the type of vaccination section since this study is single-blind. It is to be noted that some of the questionnaires need to be clarified as single or multiple-choice. Overall, this CRF is quite easy to understand but some of the questionnaires that contribute to the finding of the study are still missing. Following the provided suggestion will surely improve the quality of your CRF.