Reply To: Week 4 Topic 3 CDSS

[Penpitcha Thawong]

My organization, DMSC, services HLA allele-specific genotyping Method for prevention of severe cutaneous adverse drug reactions: severe cutaneous adverse drug reaction (SCAR) and Johnson syndrome/Toxic Epidermal Necrolysis (SJS/TEN). 3 medicines show a high incidence of adverse drug resistance including Carbamazepine, Allopurinol, and Abacavir. Therefore, if a patient has got a causative allele we will report to the hospital for avoiding the use of that medicine. I don’t know this example can be CDSS or not, however, the incidence of severe cutaneous adverse drug reactions was significant decrease after we have the service.